Welcome to the Baker Lab
Deconstructing the form and function of molecular recognition in the immune system
We study the principles of molecular recognition in the immune system, connecting structural biology, protein biophysics, and immunology. Through this interdisciplinary work we work to understand the mechanisms by which the immune system recognizes and distinguishes between targets and how target recognition leads to immunological outcomes. In addition to the fundamentals of this beautifully complicated biology, we are interested in understanding immunological responses in infection, autoimmunity, transplantation, and cancer. Through our many collaborations we have also projects in vaccines, biologics, and cell therapy. Stop by, see our work, and join the fun!
Latest Publications
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Featured Projects
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Structural biophysics of T cell specificity
Melding structural biology, biophysics, and immunology to learn what T cell receptors see and why, and how this drives the fundamental biology of cellular immunity
Neoantigen-based cancer vaccines
Understanding how neoantigens induce anti-tumor immunity and how to predict and improve them for therapeutic and preventative vaccination against cancer
T cell degeneracy in transplantation
Bringing our knowledge of how T cell receptors recognize targets to improve outcomes in organ transplantation
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