Welcome to the Baker Lab

Deconstructing the form and function of molecular recognition in the immune system

We study the principles of molecular recognition in the immune system, connecting structural biology, protein biophysics, and immunology. Through this interdisciplinary work we work to understand the mechanisms by which the immune system recognizes and distinguishes between targets and how target recognition leads to immunological outcomes. In addition to the fundamentals of this beautifully complicated biology, we are interested in understanding immunological responses in infection, autoimmunity, transplantation, and cancer. Through our many collaborations we have also projects in vaccines, biologics, and cell therapy. Stop by, see our work, and join the fun!

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Featured Projects

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Illustration describing the force dependence of T cell receptor binding, highlighting the project on the biophysics of T cell recognition

Structural biophysics of T cell specificity

Melding structural biology, biophysics, and immunology to learn what T cell receptors see and why, and how this drives the fundamental biology of cellular immunity

Illustration of the structure of a T cell receptor in complex with the HHAT ovarian cancer antigen, highlighting the lab's project on neoantigens and cancer vaccines

Neoantigen-based cancer vaccines

Understanding how neoantigens induce anti-tumor immunity and how to predict and improve them for therapeutic and preventative vaccination against cancer

Illustration of the how alloreactive TCR 1406 binds, highlighting the lab's research into alloreactivity and organ transplant rejection

T cell degeneracy in transplantation

Bringing our knowledge of how T cell receptors recognize targets to improve outcomes in organ transplantation

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